OSU Researchers Look at New Way to Fight Infection

Researchers at the Ohio State University may have figured out a novel way to fight diseases including HIV or autoimmune disorders might involve an enzyme called SAMHD1 that works on the immune system–according to new research at OSU.

SAMHD1 is a neutral in terms of good or bad–but it seems blocking its activity could stop the progression of diseases of the immune system. The current research was completed on human and mouse immune cells and was published in the Proceedings of the National Academy of Sciences. SAMHD1 was first discovered in 2000 and has been known to been linked to such disorders of the immune system like HIV and cancer.

Figuring out how SAMHD1 affects an immune diseases progressing is the goal of the new research.The new research demonstrates that SAMHD1 interacts with several cellular proteins that regulate innate immune responses. Most importantly they have learned it can act as an inhibitor for harmful bodily responses to viral infection.