In a study published in the journal Scientific Reports, researchers from the Ohio State University’s Wexler Medical Center found that the time of day during which breast cancer chemotherapy drugs are given affect the amount of damaging inflammation that occurs within the body.
It is believed that inflammation that can happen in the brain due to these drugs is what causes a lot of the neurological side effects such as depression, anxiety and short-term memory loss. And researchers are hoping that through understanding why the timing of doses affects the level of inflammation they can reduce it and its damaging effects.
The results also showed an important complicating factor: The inflammatory effects were opposite in the brain versus the spleen depending on the time the drugs were given. While researchers don’t fully understand the either of these discoveries or their implications, this line of research could lead to discoveries that make side-effect heavy cancer treatments like chemo safer for patients.